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Glutamate and Addiction
Herman, Barbara H. (Clinical Medical Branch, Division of Treatment Research and Development, NIDA, NIH, Bethesda, MD)
Frankenheim, Jerry (PICNRB, DNBR, NIDA, NIH, Bethesda, MD)
Litten, Raye Z. (Chief, Treatment Research Branch, Division of Clinical and Prevention Research, NIAAA, NIH, Bethesda, MD)
Sheridan, Philip H. (Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, Office of Drug Evaluation, FDA, Rockville, MD)
Weight, Forrest F. (Laboratory of Molecular & Cellular Neurobiology, Division of Intramural Clinical and Biological Research, NIAAA, NIH, Bethesda, MD)
Zukin, Stephen R. (Division of Treatment Research and Development, NIDA, NIH, Bethesda, MD)
Abstract:
In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the “glutamate cascade” to determine their roles in various addictive states.
Binding: Hardcover
Pub. Date: August 2002
Pages: 464
ISBN: 0-89603-879-3
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