Antibiotics: Actions, Origins, Resistance
Author: Christopher Walsh
Book ISBN: 1-55581-254-6
About the Book
This new text offers a comprehensive, up to date account of those structural classes of antibiotics that have had an impact in human infectious disease. While most of the attention is on natural products with antibiotic activity elaborated by microbes to act as chemical weapons on neighboring bacteria, synthetic chemicals with antibiotic activity are also discussed.
The book opens with an introduction to antibiotics, followed by a section that examines how antibiotics block specific proteins acting in these essential bacterial processes and how the molecular structure of the small-molecule drugs enables their antibiotic activity. Section III explores the development of bacterial resistance to antibiotics, including the molecular logic that microbial producers of antibiotics use for self-protection. The fourth section addresses the molecular logic of antibiotic biosynthesis, starting with regulatory networks that control gene transcription of secondary metabolites in streptomycetes. The final section examines the prospects for broadening the base of bacterial targets and also where new antibiotics are likely to emerge, including both synthetic chemical efforts and natural products.
Key Features
· Provides chemical focus on antibiotic structures and how they interact with bacterial targets
· Examines the evolution of resistance mechanisms from antibiotic producers
· Offers insights on antibiotic targets from bacterial genomics
· Analyzes molecular logic for regulation of antibiotic pathways
Number of Pages: 345
Publication Date: Feb 6 2003
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