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- 內容介紹
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Principles of Bone Biology, Two-Volume Set, 3rd Edition Volume 1-2
Edited by John P. Bilezikian, Lawrence G. Raisz and T. John Martin
1900 pages
Trim size 8 1/2 X 10 7/8 in
Copyright 2008
Key Features
Provides a “one-stop” shop. There is no need to search through many research journals or books to glean the information one wants…it is all in one source written by the experts in the field.
THE essential resource for anyone involved in the study of bones and bone diseases.
Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.
Readers can easily search and locate information quickly as it will be online with this new edition.
Readership
Academic and medical libraries as well as professionals in bone biology, endocrinology, and osteology
Table of Contents
Part I Basic Principles A. Cell Biology Chapter 1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity Ego Seeman Chapter 2: Biomechanics of Bone Elise Morgan Chapter 3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation Andrew Karaplis Chapter 4: Mesenchymal Stem Cells & Osteoblast Lineage Jane Aubin Chapter 5: Transcriptional Control of Osteoblast Differentiation and Function Thorsten Schinke Chapter 6: Wnt Signaling and Bone Mark Johnson Chapter 7: Sclerostin and Bone Rutger van Bezooijen Chapter 8: The Osteocyte Jenneke Klein-Nulend Chapter 9: Cells of Bone: Osteoplast Generation Tatsuo Suda Chapter 10: Osteoclast Function: Biology and Mechanisms Kalervo Vaananen Chapter 11: RANK Signaling Hiroshi Takanayagi Chapter12: Regulating Bone Resorption Roland Baron Chapter 13: Apoptosis in Bone Cells Stavros Manolagas Chapter 14: Skeletal Gene Expression in Nuclear Microenvironments Gary Stein B. Biochemistry Chapter 15: Type I Collagen: Structure, Synthesis, and Regulation Benoit de Crombrugghe Chapter 16: Collagen Crosslinking & Metabolism Simon Robins Chapter 17: Bone Matrix Proteoglycans & Glycoproteins Pamela Robey Chapter 18: Osteopontin Masaki Noda Chapter 19: Bone Proteinases Nicola Partridge Chapter 20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells Michael Horton Chapter 21: Intercellular Junctions and Cell-Cell Communication in the Skeletal System Roberto Civitelli C. Bone Remodeling and Mineral Homeostasis Chapter 22: Histomorphometric Analysis of Bone Remodeling David Dempster Chapter 23: Phosphorus Homeostasis & Related Disorders Marc Drezner Chapter 24: Magnesium Homeostasis Robert Rude Chapter 25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro Felix Bronner Chapter 26: Biology of the Extracellular Ca2+-Sensing Receptor Edward Brown D. The Hormones of Bone Chapter 27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein John Potts Chapter 28: Parathyroid Hormone - Molecular Biology Hank Kronenberg Chapter 29: Parathyroid Hormone-Receptor Interactions Mike Rosenblatt Chapter 30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System John Bilezikian Chapter 31: The Vascular and Cardiovascular Actions of PTH John Bilezikian Chapter 32: PTH and PTHrP Actions on Kidney and Bone Peter Friedman Chapter 33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein John Wysolmerski Chapter 34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein Thomas Clemens Chapter 35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses Tony Norman Chapter 36: Vitamin D Gene Regulation Sylvia Christakos Chapter 37: Photobiology and Non-Calcemic Actions of Vitamin D Mike Holick Chapter 38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects Bob Gagel Chapter 39: Amylin and Calcitonin Gene-Related Peptide Jill Cornish E. Other Systemic Hormones That Influence Bone Metabolism Chapter 40: Estrogens & Progestins Russell Turner Chapter 41: The Pharmacology of Selective Estrogen Receptor Modulators Henry Bryant Chapter 42: Mechanisms of Estrogen Action in Bone Roberto Pacifici Chapter 43: Thyroid Hormone & Bone Paula Stern Chapter 44: Clinical and Basic Aspects of Glucocorticoid Action in Bone Barbara Kream Chapter 45: Effects of Diabetetes & Insulin on Bone Physiology Johan Verhaeghe Chapter 46: Androgens:Receptor Expression and Steroid Action in Bone Kristine Wiren Chapter 47: Kinins & Neuro-Osteogenic Factors Ulf Lerner Chapter 48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals Patricia Ducy F. Local Regulators Chapter 49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology Cliff Rosen Chapter 50: Platelet-Derived Growth Factor & the Skeleton Ernesto Canalis Chapter 51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone Marja Hurley Chapter 52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling Dwight Towler Chapter 53: Transforming Growth Factor-â Sarah Dallas Chapter 54: Bone Morphogenetic Proteins and the Skeleton Vicki Rosen Chapter 55: Bone Morphogenetic Protein Receptors & Actions Kohei Miyazono Chapter 56: Colony-Stimulating Factor-1 Willy Hofstetter Chapter 57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines Mark Horowitz Chapter 58: Prostaglandins & Bone Metabolism Carol Pilbeam Part II Molecular Mechanisms of Metabolic Bone Disease Chapter 59: Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis Sunil Wimalawansa Chapter 60: Molecular Basis of PTH Overexpression Andy Arnold Chapter 61: Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism Ghada EI-Hajj Fuleihan Chapter 62: Multiple Endocrine Neoplasia Type I Maria Luisa Brandi Chapter 63: Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy David Goltzman Chapter 64: Local Factors in Skeletal Malignancy Greg Mundy Chapter 65: Genetic Regulation of the Parathyroid Gland Development Raj Thakker Chapter 66: Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations Harald Jueppner Chapter 67: Diseases Resulting from Defects in the G Protein Gs Lee Weinstein Chapter 68: Renal Osteodystrophy – Pathogenic Mechanisms and Therapeutic Options Bill Goodman Chapter 69: Osteogenesis Imperfecta David Rowe Chapter 70: Hereditary Deficiencies in Vitamin D Action Uri Liberman Chapter 71: Oncogenic Osteomalacia Suzanne Jan de Beur Chapter 72: Osteopetrosis Lyndon Key Chapter 73: Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans Michael Whyte Chapter 74: Paget's Disease of Bone Fred Singer Chapter 75: Genetic Determinants of Bone Mass and Osteoporotic Fracture Stuart Ralston Chapter 76: Pathophysiology of Osteoporosis Bilezikian, Raisz, Martin Chapter 77: Evaluation of Risk for Osteoporosis Fracture Stuart Silverman Part III Pharmacological Mechanisms of Therapeutics Chapter 78: Parathyroid Hormone Dave Hanley Chapter 79: Calcium Robert Heaney Chapter 80: Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics Edward Nemeth Chapter 81: Bisphosphonates: Mechanisms of Action Graham Russell Chapter 82: The Pharmacology of Estrogens in Osteoporosis Robert Lindsay Chapter 83: Vitamin D & Analogs Glenville Jones Chapter 84: Estrogen Effects on Bone in the Male Skeleton Luigi Gennari Chapter 85: Mechanisms of Exercise Effects on Bone Quantity and Quality Clint Rubin Part IV Methods in Bone Research Chapter 86: Application of Transgenic Mice to Problems of Skeletal Bone Stephen Clark Chapter 87: Biochemical Markers of Bone Metabolism Markus Seibel Chapter 88: Methods and Clinical Issues in Bone Densitometry Glen Blake Chapter 89: Controversial Issues in Bone Densitometry Paul Miller Chapter 90: Macro and Micro Imaging of Bone Architecture Klaus Engelke, Sven Prevrhal, and Harry K. Genant
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