Fatty Liver Disease: NASH and related disorders
Edited By: Geoff Farrell, University of Sydney, Australia
Jacob George, University of Sydney
Pauline Hall, University of Cape Town
Arthur McCullough, Case Western Reserve University, Ohio
246 x 189mm, 7.5 x 9.75in
Fatty liver disease, especially non-alcoholic steatohepatitis (NASH), is emerging as the most common form of liver disease - affecting at least 5% of the population of western countries with increasing incidence in developing economies in other continents (particularly Asia, South America and South Africa).
NASH is the form of fatty liver disorder which can result in cirrhosis, particularly in those with diabetes or who are overweight, yet it is still not widely recognised despite its already high and increasing prevalence worldwide. This book explains what NASH is, why it happens, who gets it, how it can result in cirrhosis, when to think about it, how to select practical management between those with a minor abnormality from those who may have cirrhosis, and how to prevent and treat this ubiquitous condition.
Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It should appeal to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease.
There is a dearth of assembled information about NASH: such information is sought by physicians of various backgrounds, and detailed information is required by gastroenterologist, hepatologists, general physicians, diabetologists, nutritionalists and pathologists. Information on the diagnosis, management and understanding of this disease is only available in recent reviews - it is not covered in standard texts and there is no specific book available on the subject so far.
The reader will benefit from the book by improving their diagnostic acumen for people with abnormal liver tests, improving knowledge about an important subject that will assist them in specialist or undergraduate exams, and will improve management of a common disorder.
1 Overview: an introduction to NASH and related fatty liver disorders
2 Pathology of hepatic steatosis, NASH and related conditions
3 The epidemiology and risk factors of NASH
4 Insulin resistance in NAFLD: potential mechanisms and therapies
5 NASH as part of the metabolic (insulin resistance) syndrome
6 NASH is a genetically determined disease
7 The pathogenesis of NASH: human studies
8 Animal models of steatohepatitis
9 Fatty acid metabolism and lipotoxicity in the pathogenesis of NAFLD/NASH
10 Cytokines and inflammatory recruitment in NASH: experimental and human studies
11 Mitochondrial injury and NASH
12 Cell biology of NASH: fibrosis and cell proliferation
13 Clinical manifestations and diagnosis of NAFLD
14 The clinical outcome of NAFLD including cryptogenic cirrhosis
15 Practical approach to the diagnosis and management of people with fatty liver diseases
16 Management of NASH: current and future perspectives on treatment
17 NAFLD, NASH and orthotopic liver transplantation
18 NAFLD/NASH is not just a ‘Western’ problem: some perspectives on NAFLD/NASH from the East
19 NAFLD/NASH in children
20 Steatohepatitis resulting from intestinal bypass
21 Specific disorders associated with NAFLD
22 Hepatocellular carcinoma in NAFLD
23 Does NASH or NAFLD contribute to comorbidity of other liver diseases?
24 Recent advances