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Cholinergic Mechanisms
Israel Silman, Lili Anglister, Abraham Fisher, Daniel M Michaelson, Hermona Soreq
Publisher: Taylor & Francis
ISBN: 1841840750
Pub Date: 19 AUG 2004
Type: Hardback Book
The cholinergic synapse is an important interdisciplinary research topic for two principal reasons:
1. Its intrinsic value as a system of choice for investigating many fundamental issues of development, structure and function/malfunction of synapses in general;
2. Due to its crucial biological role, it is the target of a variety of natural toxins and synthetic poisons and drugs.
For example, it is the target of the first generation of anti-Alzheimer drugs, of nerve agents and insecticides, of botulinum toxin and the South American Indian arrow poison, curare, and of drugs for the treatment of myasthenia gravis and glaucoma. Thus a large body of neuroscientists, with a broad range of interests, focus their research on this synapse. The triennnial symposium on cholinergic mechanisms provides a key multidisciplinary forum for their interaction, and the proceedings of the XIth ISCM, held in St Moritz in May 2002, provide a cutting edge profile of research progress in this important field of research.
Contents:
Platform Presentations Edith Heilbronn Lecture 1. In Memoriam: Edith Heilbronn Nicotinic Receptors: Structure 2. Nicotinic Acetylcholine Aeceptors: Probing Functionally Significant Structural Changes with Site-directed Reactions 3. The Binding Site for ?-bungarotoxin in the Acetylcholine Receptor: From Synthetic Peptides to Solution and Crystal Structure 4. Pharmacological and Structural Characterization of the Interaction of Snake Toxins with Nicotinic Acetylcholine Receptors 5. Structure and Dynamics of Acetylcholine Receptor and its Lipid Microenvironment: From Molecule to Cell 6. Site-directed Reactive Probes for Structural and Functional Investigation of Cholinergic Proteins 7. The Mechanism for Acetylcholine Receptor Inhibition by ?-neurotoxins and Species-specific Resistance to ?-bungarotoxin Revealed by NMR Muscarinic Receptors: Structure 8. Structure and Activation of Muscarinic Acetylcholine Receptors 9. Generation and Analysis of Muscarinic Acetylcholine Receptor Knockout Mice 10. Roles of External Loops of Muscarinic Receptors in Interactions Between N-methylscopolamine and Allosteric Modulators Couteaux Lecture 11. René Couteaux (1909-1999) and His Presynaptic Active Zone 12. Ligand Recognition in the Cholinergic Nervous System Analysed by Structural Templates and Protein Dynamics
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