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Clinical Trials in Heart Disease, 2nd Edition - A Companion to Braunwald’s Heart Disease
By JoAnn Manson, MD, DrPH,
Professor of Medicine, Harvard Medical School; Chief, Division of Preventive Medicine, Brigham and Women's Hospital, Boston
Julie E. Buring, ScD, Paul M. Ridker, MD, MPH and J. Michael Gaziano, MD, MPH
Approx. 448 pages, Copyright 2004
Description
This new edition covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice. This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered.
Key Features
Evidence-based research to guide clinical practice.
Coverage of treatment trials including Glycoprotein IIb/IIa receptor inhibitors, aspirin, drug therapies for arrhythmias, and pacing.
Expanded section on prevention of cardiac disease
Covers both prevention and treatment.
New to this Edition
Data and Safety Monitoring Boards in Randomized Trials
Coronary Artery Bypass Surgery
Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy
Postmenopausal Hormone Therapy
Table of Contents
Section I. METHODOLOGY
Chapter 1: Contributions of Basic Research, Observational Studies, and Randomized Trials Chapter 2: Methodology of Randomized Trials Chapter 3: Comparative Features of Primordial, Primary and Secondary Prevention Trials Chapter 4: Principles of Data and Safety Monitoring Boards in Randomized Trials
Section II. TREATMENT TRIALS
A. Treatment of Acute Coronary Ischemia
Chapter 5: Aspirin and Thienopyridines Chapter 6: Heparin and Low Molecular Weight Heparin in Acute Coronary Ischemia Chapter 7: Clinical Trials in Thrombolytic Therapy Chapter 8: Clinical Trials of Direct Thrombin Inhibitors Chapter 9: Glycoprotein IIb/IIIa Receptor Inhibitors Chapter 10: Adjunctive Medical Therapy for Acute Myocardial Infarction Chapter 11: Primary, Rescue and Adjunctive Mechanical Intervention in the Setting of Acute Myocardial Infarction Chapter 12: Coronary Artery Bypass Surgery in Acute Coronary Syndromes
B. Treatment of Arrhythmias
Chapter 13: Drug Therapy for Ventricular Tachycardia and Ventricular Fibrillation Chapter 14: Antiarrhythmic Drug Therapy in Supraventricular Tachycardia Chapter 15: Anticoagulant and Antiplatelet Drug Therapy for Atrial Fibrillation Chapter 16: Clinical Trials in Arrhythmia Ablation Chapter 17: Clinical Trials of Implantable Cardioverter-Defibrillators (ICDs) and Cardiac Resynchronization Therapy/Defibrillation Chapter 18: Clinical Trials in Pacing
C. Treatment of Congestive Heart Failure
Chapter 19: Drugs Blocking the Renin-Angiotensin-Aldosterone System (RAAS) Chapter 20: Beta-blocker Treatment of Heart Failure Chapter 21: Clinical Trials in Heart Transplantation and Mechanical Cardiac Support for End-Stage Heart Failure
Section III. PRIMARY AND SECONDARY PREVENTION TRIALS
Chapter 22: Cholesterol Reduction Chapter 23: Blood Pressure Reduction Treatment Trials Chapter 24: Prevention Trials of Smoking Cessation Chapter 25: Physical Activity and Weight Loss Chapter 26: Aspirin, Other Antiplatelet Agents, and Anticoagulant Agents in the Secondary and Primary Prevention of Cardiovascular Disease Chapter 27: Postmenopausal Hormone Replacement Therapy Chapter 28: Antioxidant Vitamins Chapter 29: Dietary Factors Chapter 30: Cardiac Psychology/Behavioral Cardiology Chapter 31: Multiple Risk Factor Intervention Trials Chapter 32: Prevention Strategies: From the Office to the Community and Beyond
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