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Neonatal and Pediatric Pharmacology Therapeutic Principles in Practice Hardbound
Author(s):
Sumner J Yaffe
Jacob V Aranda MD, PhD, FRCP(C)
Edition: Fourth
ISBN-10: 0-7817-9538-9
ISBN-13: 978-0-7817-9538-8
Pub Date: October 2010
Pages: 1072
Illustrations: 131
Trim Size: 8.375 x 10.875
Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.
The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta
--NEW: New chapter on nutrient supplements
--NEW: New chapter on biotransformation of medications by human placenta
--NEW: Updated information on drug interactions
--NEW: Updated information on federal legislation
--Evidence-based discussion of drugs in pediatric population
--State-of-the-art discussion of what is known about the basic science of drugs in pediatrics
--Written and edited by the foremost authorities in pediatric clinical pharmacology
Table Of Contents
I: GENERAL PRINCIPLES
1: Introduction and Historical Perspectives
2: Clinical Pharmacokinetics in Infants and Children
3: Drug Action and Therapy in the Infant and Child
4: Drug Metabolism and Disposition in Infants and Children
5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics
6: Compliance with Pediatric Medication Regimens
7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations
8: Ethics of Drug Research in Pediatric Populations
9: Therapeutic Drug Monitoring
10: Drug Formulations
II: DRUGS AND THE NEWBORN
11: Developmental Toxicology
12: Biotransformation of Medications by Human Placenta
13: Maternal Drug Intake and the Newborn
14: Principles of Neonatal Pharmacology
15: Perinatal Origins of Adult Defects in Drug Metabolism
16: Renal Function and Excretion of Drugs in the Newborn
17: The Excretion of Drugs and Chemicals in Human Milk
18: Drugs for Hyperbilirubinemia
19: Drugs and Lung Development
20: Pharmacologic Treatment of Neonatal Apnea
21: Drugs and Perinatal Brain Injury
22: Antiretroviral Pharmacology in Pregnant Women and Newborns
III: DRUGS IN SPECIAL POPULATIONS AND SETTINGS
23: Therapeutic Applications in Pediatric Intensive Care
24: Drug Therapy in the Pediatric Emergency Department
25: Drug Therapy in the Adolescent
26: Topical Medications
27: Ophthalmologic Drugs in Infants and Children
IV: SPECIFIC DRUGS
28: Sulfonamides
29: Penicillins, Cephalosporins, and Other Beta-Lactams
30: Aminoglycosides and Glycopeptides
31: Fluoroquinolones
32: Macrolides, Chloramphenicol, and Tetracyclines
33: Anthelminthic Drugs in Children
34: Antituberculosis Drugs
35: Antifungal Agents
36: Antiviral Drugs: Treatment of the Fetus and Newborn
37: Anticonvulsants
38: Psychopharmacology in Children and Adolescents
39: Antihistamine Drugs
40: Antiasthmatics
41: Antipyretics
42: Cardiovascular Drugs
43: Diuretics
44: Clinical Pharmacology of Antineoplastic Drugs
45: Immunosuppressive and Immunomodulatory Drugs
46: Analgesic Agents
47: Local Anesthetics for Infants and Children
48: Nonsteroidal Anti-inflammatory Drugs
49: Antihypertensive Agents
50: Gastrointestinal Drugs
51: Glucocorticoids
52: Insulin and Diabetes Mellitus
53: Thyroid Hormones
54: Growth Hormone
55: Hematologic Agents
56: Nutrient Supplements
57: Childhood Vaccines
V: ADVERSE DRUG EFFECTS AND INTERACTIONS
58: Epidemiology of Adverse Drug Effects
59: Mechanisms of Adverse Drug Reactions
60: Medication Errors
61: Pediatric Poisonings and Antidotes
62: Use of Herbal Products in Children: Risks and Unproven Benefits
63: Neonatal Abstinence Syndromes
64: Drug Interactions in Newborns and Children
VI: APPENDIX
65: Drug Formulary for the Newborn
66: Pediatric Drug Formulary
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