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Muscle Biopsy, 3rd Edition - A practical approach
By Victor Dubowitz, BSc, MD, PhD, FRCP, DCH and Caroline A. Sewry, BSc, PhD, FRCPath
626 pages 553 ills
Trim size 7 7/16 X 9 11/16 in
Copyright 2007
Description
In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.
Key Features
Covers the entire range of diagnostic/investigative techniques, providing you with all of the necessary tools to formulate an accurate diagnosis.
Offers a combination of clinical and pathological experience for a unique perspective on a complex and difficult area of diagnosis.
Addresses the “knowledge explosion” over the last 10 years in the fields of molecular genetics and immunocytochemistry, including all of the latest clinically relevant investigative techniques.
Focuses on diagnostic techniques and on the diagnostic interpretation of results, giving you a portable reference book and a bench book in a single volume.
New to this Edition
Presents all the latest techniques in molecular diagnosis and immunocytochemistry as they apply to individual disorders.
Includes high-quality, full-color illustrations throughout the book.
Incorporates tables, summary charts, and boxes to provide a user-friendly, accessible format.
Table of Contents
Section 1 The Biopsy: Normal and Diseased Muscle
1. The procedure of muscle biopsy
2. Histological and histochemical stains and reactions
3. Normal muscle
4. Definition of pathological changes seen in muscle biopsies
5. Ultrastructural changes in diseased muscle
6. Immunohistochemistry
7. How to read a biopsy
Section 2 Pathological Muscle: Individual Diseases
8. Classification of neuromuscular disorders
9. Neurogenic disorders
10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy
11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies
12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies
13. Muscular dystrophies and allied disorders IV: Emeryƒ{Driefuss muscular dystrophies and Bethlem myopathy
14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy
15. Congenital myopathies
16. Myofibrillar myopathies
17. Metabolic myopathies I: glycogenoses
18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies
19. Endocrine disorders
20. Ion channel disorders
21. Myasthenic syndromes
22. Inflammatory myopathies
23. Toxic and drug-induced myopathies Russell Lane, Charing Cross Hospital
Appendix 1. Glossary of commonly used terms
References
Index
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