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Hematology, 4th Edition - Basic Principles and Practice
By Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Sanford J. Shattil, MD, Bruce Furie, MD, Harvey J. Cohen, MD, PhD, Leslie E. Silberstein, MD and Philip McGlave, MD
Approx. 2864 pages, Copyright 2005
Description
The fourth edition of this leading text reflects the new direction and growth of the field of hematology as an academic and clinical discipline. Edited and written by practitioners who are the leaders of the field, the book covers both the basic scientific foundations of hematology and its clinical aspects. It provides practitioners with the most comprehensive, authoritative, up-to-date information in hematology. The table of contents has been thoroughly revised with many new chapters added, reflecting the rapidly changing nature of the molecular and cellular areas of the specialty. This definitive resource is the one comprehensive book needed by every practicing hematologist.
Key Features
Full color throughout for the first time (color figures in place!)
E-dition available
The definitive, complete reference resource for hematologic disorders provides “one-stop shopping” for information; appeals to both practitioners and researchers
Red “opinion” boxes contain treatment strategies and recommendations by the experts
Only text to include a section on transplantation
Clinically oriented focus
Includes more than 15 new chapters
Table of Contents
Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
Chapter 1 Anatomy and Physiology of the Gene Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner
Chapter 2 Genomic Approaches to the Study of Hematologic Science Todd Golub and Scott Armstrong
Chapter 3 Protein Synthesis, Processing, and Degradation Garabet G. Toby and David L. Wiest
Chapter 4 Protein Architecture: Relationship of Form and Function Alan C. Rigby and Barbara C. Furie
Chapter 5 Regulation of Cellular Response Benjamin G. Neel and Christopher Carpenter
Chapter 6 Cell Adhesion Rodger P. McEver
Chapter 7 Control of Cell Division William M.F. Lee and Chi V. Dang
Chapter 8 Cell Death David M. Hockenbery and Stanley J. Korsmeyer
Chapter 9 Pharmacogenomics and Hematological Diseases Loe Kager and William E. Evans
Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY
Chapter 10 Overview and Compartmentalization of the Immune System Leland D. Powell and Linda G. Baum
Chapter 11 B-Cell Development Kenneth Dorshkind and David J. Rawlings
Chapter 12 T-Cell and NK-Cell Immunity Carol Clayberger and Alan M. Krensky
Chapter 13 Dendritic Cell Biology Zbigniew M. Szczepiorkowski and Nina Bhardwhaj
Chapter 14 Regulation of Activation of B and I Lymphocytes John C. Monroe and Lawrence Turka
Chapter 15 Leukocyte Trafficking James J. Campbell, Steven Sloan, and Leslie E. Silberstein
Chapter 16 Tolerance and Autoimmunity Mark J. Shlomchik
Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS
Chapter 17 Stem Cell Model of Hematopoiesis Anskar YH Leung and Catherine M. Verafaillie
Chapter 18 Bone Marrow Microenvironment Mo Dao and Catherine M. Verfaillie
Chapter 19 The Humeral Regulation of Hematopoiesis Montaser Shaheen and Hal Broxmeyer
Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation Thalia Papayannopoulou, Alan D’Andrea, Janis Abkowitz, and Anna Rita Migliaccio
Chapter 21 Granulopoiesis and Monocytopoiesis Arati Khanna-Gupta and Nancy Berliner
Chapter 22 Thrombocytopoiesis Michael W. Long and Ronald Hoffman
Chapter 23 Thrombocytopenia Due to Decreased Platelet Production J. B. Opalinska and Alan M. Gewirtz
Chapter 24 Inherited Forms of Bone Marrow Failure Melvin H. Freedman
Chapter 25 Aplastic Anemia Neal S. Young and Jaroslaw P. Maciejewski
Chapter 26 Paroxysmal Nocturnal Hemoglobinuria Rob A. Brodsky
Chapter 27 Pure Red Cell Aplasia Emmanuel N. Dessypris
Part IV. RED BLOOD CELLS
Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert
Chapter 29 Approach to Anemia in the Adult and Child Peter Marks and Bertil Glader
Chapter 30 Anemia of Chronic Diseases Lawrence B. Gardner and Edward J. Benz, Jr.
Chapter 31 Pathology of Iron Metabolism Nancy C. Andrews
Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload Gary M. Brittenham
Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias James S. Wiley and Michael R. Moore
Chapter 34 Megablastic Anemias Aœok C. Anthony
Chapter 35 Thalassemia Syndromes Bernard G. Forget and Alan R. Cohen
Chapter 36 Pathology of Sickle Cell Disease Robert P. Hebbel
Chapter 37 Sickle Cell Disease Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah
Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias Edward J. Benz, Jr.
Chapter 39 Red Cell Enzymopathies Xylina T. Gregg and Josef T. Prchal
Chapter 40 Red Cell Membrane Disorders Patrick G. Gallagher and Petr Jarolim
Chapter 41 Autoimmune Hemolytic Anemias Melody J. Cunningham and Leslie E. Silberstein
Chapter 42 Extrinsic Nonimmune Hemolytic Anemias Stanley L. Schrier and Erin Gourley Reid
Part V. HOST DEFENSE AND ITS DISORDERS
Chapter 43 Complement Biology and Immunoglobulin Gregory Kline, Robert Barrington, and Michael C. Carroll
Chapter 44 Normal Phagocyte Structure and Function Robert L. Baehner
Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes Steven J. Ackerman and Joseph H. Butterfield
Chapter 46 Disorders of Phagocyte Function and Number Mary C. Dinauer and Thomas D. Coates
Chapter 47 Disorders of Lymphocyte Function Aileen M. Cleary, Richard A. Insel, and David B. Lewis
Chapter 48 Histiocytic Disorders Jeffrey M. Lipton and Robert J. Arceci
Chapter 49 Lysosomal Storage Diseases: Perspective and Principles Gregory A. Grabowski and Nancy Leslie
Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop
Chapter 51 The Spleen and Its Disorders Susan B. Shurin
Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis Robert I. Parker and Dean D. Metcalfe
Part VI. HEMATOLOGIC MALIGNANCIES
Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological Malignancies Gordon Dewald and Rhett P. Ketterling
Chapter 54 The Molecular Basis of Neoplasia Carol Westbrook
Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis
Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies Andrea K. Ng and Peter M. Mauch
Chapter 57 Clinical Use of Hematopoietic Growth Factors Jacob M. Rowe and Irit Avivi
Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma Thomas E. Witzig
Chapter 59 Pathobiology of Acute Myeloid Leukemia Brian Huntly and D. Gary Gilliland
Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia Kenneth B. Miller and Philip R. Daoust
Chapter 61 Therapy for Acute Myeloid Leukemia Elihu H. Estey and Hagop Kantarijan
Chapter 62 Acute Myeloid Leukemia in Children Gary V. Dahl and Howard J. Weinstein
Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia A. Thomas Look and Adolpho Ferrando
Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia Stacey L. Berg, C. Philip Steuber, and David G. Poplack
Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen
Chapter 66 Acute Lymphoblastic Leukemia in Adults Dieter Hoelzer and Nicola Gokbudget
Chapter 67 Myelodysplastic Syndrome: Biology and Treatment Richard Stone and Daniel DeAngelo
Chapter 68 Polycythemia Vera Ronald Hoffman, Kelty R. Baker and Joe Prchal
Chapter 69 Chronic Myeloid Leukemia Charles Sawyers and Neil P. Shah
Chapter 70 Myelofibrosis with Myeloid Metaplasia Ronald Hoffman and Farhad Ravandi-Kashani
Chapter 71 Essential Thrombocythemia Steven Fruchtman and Ronald Hoffman
Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz
Chapter 73 Pathobiology of Non-Hodgkin Lymphomas Gianluca Gaidano and Riccardo Dalla-Favera
Chapter 74 Patho-Biology of Hodgkin’s Lymphoma Stefano A. Pileri, Brunangelo Falini and Harold Stein
Chapter 75 Hodgkin’s Disease: Clinical Manifestations, Staging, and Therapy Volker Diehl, Daniel Re, and Andreas Josting
Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas Elaine Jaffe and Stefania Piltaluga
Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce
Chapter 78 Malignant Lymphomas in Childhood John T. Sandlund, Jr.Michael P. Link
Chapter 79 Chronic Lymphocytic Leukemia Dilip V. Patel and Kanti R. Rai
Chapter 80 Hairy Cell Leukemia Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman
Chapter 81 Cutaneous T-Cell Lymphomas Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen
Chapter 82 AIDS-Related Lymphomas David T. Scadden
Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders Guido Tricot
Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL) Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien
Chapter 85 Atypical Immune Lymphoproliferations Timothy C. Greiner and Thomas G. Gross
Chapter 86 Clinical Approaches to Infections in the Compromised Host Jo-Anne H. van Burik
Chapter 87 Nutritional Support of Patients with Hematologic Malignancies Polly Lenssen and Saundra N. Aker
Chapter 88 Psychosocial Aspects of Hematologic Disorders Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta
Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders Janet L. Abrahm, Lauren Dias, and Bridget Fowler
Chapter 90 Palliative Care Janet L. Abrahm and Barbara Sourkes
Chapter 91 Indwelling Access Devices Janet L. Abrahm and Linda M. Pellerin
Chapter 92 Late Complications of Hematologic Diseases and Their Therapies Wendy Landier and Smita Bhatia
Part VII. TRANSPLANTATION
Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome William Tse and H. Joachim Deeg
Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases Stella M. Davies
Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies Andrea Bacigalupo
Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors Stephen J. Forman and Jeffery R. Schriber
Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy Effie W. Petersdorf and Claudio Anasetti
Chapter 98 Umbilical Cord Blood Transplantation Juliet N. Barker and John E. Wagner
Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation Marcos de Lima and Sergio Giralt
Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia Pavan Reddy and James L.M. Ferrara
Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect Catherine M. Bollard and Adrian P. Gee
Chapter 102 Gene Transfer for Hematologic Disorders Katherine A. High and Malcolm K. Brenner
Chapter 103 Experimental Cell Therapy Robert S. Negrin
Chapter 104 Complications After Hematopoietic Cell Transplantation Daniel J. Weisdorf
Part VIII. HEMOSTASIS AND THROMBOSIS
Chapter 105 Megakaryocyte and Platelet Structure Joseph E. Italiano and John Hartwig
Chapter 106 The Molecular Basis for Platelet Function Edward F. Plow and Charles S. Abrams
Chapter 107 The Molecular Basis for Platelet Activation Lawrence F. Brass
Chapter 108 The Blood Vessel Wall Aly Karsan and John M. Harlan
Chapter 109 Molecular Basis of Blood Coagulation Bruce Furie and Barbara C. Furie
Chapter 110 Molecular and Cellular Basis of Fibrinolysis H. Roger Lijnen and Désiré Collen
Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants Charles T. Esmon
Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Pupura Barry S. Coller and Paul I. Schniederman
Chapter 113 Laboratory Evaluation of Hemostatic Disorders Jacob H. Rand and Lisa Senzel
Chapter 114 Structure, Biology, and Genetics of Factor VIII Randal J. Kaufman and Stylianos E. Antonarakis
Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B S. Jamie Freedman and Bruce Furie
Chapter 116 Clinical Aspects and Therapy of Hemophilia Jay Nelson Lozier and Craig M. Kessler
Chapter 117 Inhibitors in Hemophilia Donald I. Feinstein
Chapter 118 Other Clotting Factor Deficiencies Harold R. Roberts and Miguel A. Escobar
Chapter 119 Disorders of Fibrinogen José Martinez and Andres Ferber
Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor David Ginsburg and Denisa D. Wagner
Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy Gilbert C. White, II, and J. Evan Sadler
Chapter 122 Vitamin K: Metabolism and Disorders Barbara C. Furie and Bruce Furie
Chapter 123 Inhibitors of Blood Coagulation Donald I. Feinstein
Chapter 124 Disseminated Intrvascular Coagulation Howard A. Liebman and Ilene C. Weitz
Chapter 125 Hemostatic Defects Associated with Dysproteinemias Howard A. Liebman
Chapter 126 Disorders of Coagulation in the Neonate Leonardo R. Brandao and Donna DiMichele
Chapter 127 Hypercoagulable States Kenneth A. Bauer
Chapter 128 Venous Thromboembolism Mark A. Crowther and Jeffrey S. Ginsberg
Chapter 129 Arterial Thromboembolism Mark A. Crowther and Jeffrey S. Ginsberg
Chapter 130 Anticoagulation and Thrombolytic Therapy Jeffrey I. Weitz
Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura James Bussel and Douglas Cines
Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome Keith R. McCrae, J Evan Sadler, and Douglas Cines
Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism Theodore E. Warkentin and John G. Kelton
Chapter 134 Hereditary Disorders of Platelet Function Joel S. Bennett
Chapter 135 Acquired Disorders of Platelet Function Jose Lopez and Perumal Thiagarajan
Part IX. TRANSFUSION MEDICINE
Chapter 136 Human Blood Group Anitgens and Antibodies Part 1: Carbohydrate Determinants Part 2: Protein Determinants Marion E. Reid and Martin L. Olsson
Chapter 137 Human Platelet Antigens Thomas J. Kunicki and Diane J. Nugent
Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems Ena Wang, Francesco M. Marincola, and David Stroncek
Chapter 139 Principles of Red Blood Cell Transfusion Paul M. Ness and Margot S. Kruskall
Chapter 140 Principles of Platelet Transfusion Therapy Thomas S. Kickler
Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions Ronald G. Strauss
Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins Cassandra D. Josephson and Christopher D. Hillyer
Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins William N. Drohan and David B. Clark
Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies Catherine S. Manno and Peter Larson
Chapter 145 Hemapheresis and Cellular Therapy Ellen F. Lazarus and Harvey G. Klein
Chapter 146 Practical Aspects of Stem Cell Collection Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu
Chapter 147 Transfusion Reactions Edward L. Snyder and YanYun Wu
Chapter 148 Transfusion-Transmitted Diseases Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove
Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation Richard M. Kaufman, Jerome Ritz and Walter H. Dzik
Chapter 150 Red Blood Cell Substitutes Robert M. Winslow
Part X. CONSULTATIVE HEMATOLOGY
Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease Rachel Rosovsky and Peter W. Marks
Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer Peter W. Marks and David S. Rosenthal
Chapter 153 Hematologic Manifestations of AIDS David H. Henry and James A. Hoxie
Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis Mark T. Reding and Nigel S. Key
Chapter 155 Hematologic Aspects of Pregnancy Edward J. Benz, Jr.
Chapter 156 Hematologic Manifestations of Childhood Illness A. Kim Ritchey and Frank G. Keller
Part XI. SPECIAL TESTS AND PROCEDURES
Chapter 157 Bone Marrow Examination Daniel H. Ryan and Harvey J. Cohen
Chapter 158 Automated Analysis of Blood Cells Raymond E. Felgar and Daniel H. Ryan
Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias Martin H. Steinberg and David Chui
Chapter 160 Antenatal Diagnosis of Hematologic Disorders Kim Kramer and Harvey J. Cohen
Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases Michele Paessler and Adam Bagg
Chapter 162 Molecular Imaging in Hematology Francis G. Blankenberg
Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations Sharon M. Geaghan
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