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Osteoporosis in Men, 2nd Edition
The Effects of Gender on Skeletal Health
Edited by Eric S. Orwoll, John P. Bilezikian and Dirk Vanderschueren
Copyright 2010
Key Features
Brings together more eminent investigators and clinicians to interpret developments in this growing field.
Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.
There is no book on the market that covers osteoporosis in men as comprehensively as this book.
Readership
Academic, medical, and pharmaceutical researchers in bone biology, endocrinology, and rheumatology; Medical researchers in pediatrics, internal medicine, orthopedics, primary care, geriatrics, obstetrics and gynecology, oncology, and nephrology.
Quotes
"The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows."
--Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom
"The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field."
-- John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA
"This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis."
--Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy
Table of Contents
Section 1 - Essentials of bone biology
The Biochemistry of Bone: Composition and Organization
Adele L. Boskey
Bone Remodeling: Cellular Activities in Bone
David W. Dempster, Hua Zhou, Shi Shou Lu
Assessment of Bone Turnover Using Biochemical Markers
Patrick Garnero, Pawel Szulc
Fundamentals of Mineral Homeostasis
David A. Hanley, Shawn K. Davison
The Mechanical Properties of Bone
David P. Fyhrie
Assessment of Bone Architecture
Thomas F. Lang
Section 2 - Development and growth of the male skeleton
Skeletal Growth in Males
Qingju Wang, Ego Seeman
Pubertal Growth of the Male Skeleton
Vincent Gilsanz, Stefano Mora
The Effects of Sex Steroids on Bone Growth
Giampiero I. Baroncelli, Silvano Bertelloni
Nutritional Basis of Skeletal Growth
Connie M. Weaver, Elizabeth Haney
Physical Activity and Skeletal Growth
Heather M. Macdonald, Heather A. McKay, Melonie Burrows
Section 3 - Skeletal genetics
The Genetics of Peak Bone Mass
Luigi Gennari, Robert F. Klein, Serge Ferrari
Section 4 - Aging and the male skeleton
Age-Related Changes in Bone Remodeling and Micro Architecture
Roger Zebaze, Ego Seeman
Markers of Bone Remodeling and the Aging Skeleton
Serge Cremers, Christian Meier, Markus J. Seibel
Alterations in Mineral Metabolism in the Aging Male
Shonni J. Silverberg, Bismruta Misra
Change in Bone Size and Geometry with Aging
Pawel Szulc
Aging and Bone Density
Steven Boonen, Filip Callewaert, Katrien Venken, Dirk Vanderschueren
The Effect of Age on Material Properties
Charles H. Turner, Matt Allen, David Burr
Section 5, Nutritional issues
Calcium, Bone Strength and Fractures
Laura A.G. Armas, David P. Heaney, Joan M. Lappe
Vitamin D and Bone
Roger Bouillon, Christa Maes, Lieve Verlinden, Geert Carmeliet, Annemieke Verstuyf
Role of Dietary Protein in Bone Growth and Bone Loss
Rene Rizzoli
Section 6 - Sex steroids and the skeleton in men
The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes
Stavroula Kousteni
Estrogen and the Skeleton - Rodents
Dirk Vanderschueren, Katrien Venken, Filip Callewaert, Steven Boonen
Estrogen and the Skeleton - Humans
Liesbeth Vandenput, Claes Ohlsson
Androgens and the Skeleton - Animal Models
Kristine Wiren, Eric Orwoll
Androgens and the Skeleton - Humans
Benjamin Z. Leder
Androgen Effects on the Skeletal Muscle
Shalender Bhasin, Rajan Singh, Ravi Jasuja, Thomas W. Storer
Section 7 - Fractures in men
Epidemiology of Fractures
Shreyasee Amin
Individualized Progress of Fractures in Men
Tuan V. Nguyen , John A. Eisman
Physical Activity, Physical Function and Fall and Fracture Risk in Older Men
Peggy Mannen Cawthon, Lynn Marshall
Economic Impact of Osteoporotic Fractures (vs women)
Terence O’Neill
Adverse Health Outcomes in Men with Osteoporosis
Deborah T. Gold, Stuart L. Silverman
Section 8. Metabolic bone disease in men
Idiopathic Osteoporosis
Jean-Marc Kaufman, Bruno Lepauw, Youri Taes, Stefan Goemeare
Glucocorticoid Induced Osteoporosis
Andrea Giustina, Gherardo Mazziotti
Testicular Dysfunction
David J. Handelsman, Christian Meier, Markus J. Seibel
Alcohol and Bone
Neil Binkley
Transplantation Osteoporosis
Elizabeth Shane, Juliet E. Compston, Emily Stein
Management of Fractures in Men with Impaired Renal Function
Paul D. Miller
Hyperparathyroidism
John P. Bilezikian, Claudio Marccoci
Hypercalciuria
Murray J. Favus
The Skeletal Phenotype of the Male Athlete
Clifford J. Rosen, Ann E. Maloney
Inherited and Related Disorders of Bone Matrix Synthesis in Men
Jay R. Shapiro
Section 9 - Diagnostic approach
Dual-Energy X-ray Absorptiometry (DXA) in Men
Neil C. Binkley, Robert A. Adler
Quantitative Ultrasound Diagnosis of Osteoporosis in Men
Robert A. Adler, Neil C. Binkley
Advanced Structural Assessment of Bone Using CT and MRI
X. Edward Guo, X. Sherry Liu, Felix W. Wehrli
Vertebral Fracture Assessments
Piet Geusens, Willem Lems
The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis
Erik F. Eriksen, Johan Halse
Overall diagnostic strategy
Eric Orwoll
Section 10 - Therapy
Diagnostic Thresholds for Osteoporosis in Men
John A. Kanis, Anders Oden, Helena Johansson, Eugene V. McCloskey
Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges
John T. Schoesboe
Nutritional Therapy for Skeletal Health in Men
Deborah E. Sellmeyer, Diana M. Antoniucci
Exercise Programs for Patients with Osteoporosis
Dieter Felsenberg, Martin Runge
Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications
Sunil J. Wimalawansa
Treatment of Male Osteoporosis with Bisphosphonates
Socrates E. Papapoulos, Andrea Giusti
Treatment of Male Osteoporosis with Parathyroid Hormone
Monica Giotra, Felicia Cosman, John P. Bilezikian
Testosterone Therapy for Osteoporosis in Men
Kishore M. Lakshman, Andre B. Araujo, Shalendar Bhasin
57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon
Ghada El-Hajj Fuleihan, Mahmoud Tabbal
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