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Problem-Based Immunology
By Reginald M. Gorczynski, MD and Jacqueline Stanley, PhD
268 pages 65 ills
Trim size 8 X 10 in
Copyright 2006
Description
It's one thing to understand the basic science of immunology. It's another thing to know how that science applies to the realities of patient care. This new resource uses skillfully presented clinical case studies to efficiently demonstrate the practical relevance of immunology knowledge in diagnosing a wide range of challenging conditions. It offers as an ideal way to review the fundamental principles of immunology ... and see them translated into real-world diagnosis and management!
Key Features
Covers each major area of the field – immunization, hypersensitivity, autoimmunity, immunodeficiency disorders, tumor immunology, and transplantation.
Provides a concise overview of the basic concepts in each area, followed by 6-10 succinct and well-organized case studies that illustrate the associated clinical applications.
Begins each case study with an initial case presentation, complete with full-color clinical photographs, allowing you to put your diagnostic reasoning skills to the test – followed by a list of the key clinical features involved in the case • a one-paragraph discussion of each differential diagnostic possibility • and a summary of the correct diagnosis and treatment approach
Table of Contents
IMMUNIZATION
Background
• Rationale for immunization • General principles of immunization • Broad classes of vaccines • Role of adjuvants • Vaccine efficacy and safety • Vaccine strategies in development • Novel vaccine applications
Cases
1. Deliberate natural immunization (Leishmania) 2. Immunization in the bioterrorist era; small pox (or anthrax) 3. Immunization in the elderly (influenza) 4. Passive immunization: tetanus toxoid 5. Novel approaches for HIV vaccines 6. Polio vaccines- Salk versus Sabin 7. Cancer vaccine
HYPERSENSITIVITY
Background
• General principles • Gell and Coombs classifications • Sensitization and effector phases of Types I-IV hypersensitivity reactions
Cases
8. Anaphylaxis 9. Asthma 10. Transfusion reaction 11. Hemolytic disease of the newborn 12. Serum sickness 13. Farmer’s lung 14. Tuberculosis 15. Poison Ivy dermatitis
AUTOIMMUNITY
Background
• General principles of tolerance induction • Current evidence/hypothesis for loss of tolerance • Evidence supporting a role for genetics in autoimmune disorders • Immunopathology associated with autoreactive antibodies • Immunopathology associated with T cell mediated damage
Cases
16. Rheumatoid arthritis 17. Systemic lupus erythematosus 18. Graves’ disease 19. Wegener’s granulomatosis 20. Insulin dependent diabetes mellitus 21. Myasthenia gravis 22. Multiple sclerosis 23. Hashimoto’s thyroiditis
IMMUNODEFICIENCY DISORDERS
Background
• General principles of primary and secondary immunodeficiency disorders • Dysfunctions that lead to primary immunodeficiency disorders affecting (a) T cells and B cells combined, (b) T cells, (c) B cells, (d) Complement, (e) phagocytes • Conditions that lead to secondary immunodeficiencies
Cases
24. Severe combined immunodeficiency disorder 25. DiGeorge’s syndrome 26. Chronic mucocutaneous candidiasis 27. Bruton’s agammaglobuliniemia (hypogammaglobulinemia) 28. Selective IgA deficiency 29. Hyper IgM syndrome 30. Chromic granulomatous disease 31. Hereditary neurotic angioedema 32. C3 complement deficiency or (C8 complement deficiency) 33. Leukocyte adhesion defect 34. Acquired immunodeficiency disorder 35. Alcoholism and secondary immunodeficiency
TUMOR IMMUNOLOGY
Background
• General principles of tumor immunology • Tumor specific antigens • Tumor associated antigens • Immunosurveillance mechanisms for eliminating tumors • Evasion of immunosurveillance • Novel therapies
Cases
36. Choriocarcinoma (?HCG ) 37. Colonic carcinoma (CEA) 38. Melanoma 39. Multiple myeloma 40. Waldenstrom’s macroglobulinemia 41. Hodgkin’s lymphoma 42. Liver (or testicular) tumor (AFP)
TRANSPLANTATION
Background
• General Features • Surgical and ischemia/reperfusion damage • Role of activated tissue macrophages and activated vascular endothelial cells • Adaptive immunity in graft rejection • Tissue matching • Non specific Immunosuppression • Specific Immunosuppression
Cases
43. Intestinal transplant 44. Pancreas transplant 45. Kidney transplant 46. Bone marrow transplant 47. Heart (or Liver) transplant
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