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- 內容介紹
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Cough: Causes, Mechanisms & Therapy
Edited By: K Fan Chung, Imperial College, London
John Widdicombe, Guy's Hospital, London, UK
Homer Boushey, University of California, San Francisco, US
Illustrations: 52
Pages: 320
Cough is the most familiar symptom of respiratory disease, and a problem which general practitioners must deal with on a daily basis. This timely volume draws together a wealth of recent research into the mechanisms, pharmacology and therapies for cough, and places these in clinical context. The text incorporates guidelines on the most common causes of cough, discusses treatments and pitfalls in management, summarizes current research on physiology, pharmacology and treatment of cough, and gives practical advice on diagnosis and management issues for the clinician.
Cough: Causes, Mechanisms and Therapy is the most comprehensive, up-to-date account of the subject. It will update clinical and basic medical scientists, and promote future research. Readers are encouraged to implement the clinical implications of the discussion into routine practice. This volume will appeal to all those involved in the treatment of respiratory disease, particularly those in hospital respiratory units, and will also be of use to interested general practitioners.
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Contents
Section 1: Introduction
1 The clinical and pathophysiological challenge of cough
2 Epidemiology of cough
3 A brief overview of the mechanisms of cough
Section 2: Cough in the clinic
4 Clinical assessment of cough
5 Measurement and assessment of cough
6 Cough sensitivity: the use of provocation tests
7 Causes, assessment and measurement of cough in children
8 The quality of life in coughers
Section 3: Clinical conditions with cough
9 Cough in lower airway infections
10 Cough in gastro-oesophageal reflux
11 Cough in postnasal drip, rhinitis and rhinosinusitis
12 Cough and airway hyperresponsiveness
13 Cough in chronic obstructive pulmonary disease (COPD)
14 Cough in suppurative airway diseases
15 Cough in cancer patients
Section 4: Pathophysiology
16 Sensory pathways for the cough reflex
17 Neurogenesis of cough
18 Plasticity of vagal afferent fibres mediating cough
19 Motor mechanisms and the mechanics of cough
20 Mucus hypersecretion and mucus clearance in cough
21 Animal models of cough
Section 5: Therapy
22 Mechanisms of actions of centrally acting antitussives - electrophysiological and neurochemical analysis
23 Pharmacology of peripherally acting antitussives
24 Current and potential future antitussive therapies
25 Placebo effects of antitussive treatments on cough associated with acute upper respiratory tract infection
26 Mucoactive agents for the treatment of cough
27 Management of cough
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